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West Sweden Asthma Study

West Sweden Asthma Study (WSAS) is the name of the strategic initiative at Krefting Research Centre (KRC). The study's main funder is the VBG Group AB / VBG GROUP Centre for Asthma and Allergy Research. The study includes several sub-studies and is also part of several international and national collaborative projects. Internationally the main collaborative projects are the EU-supported GA2LEN project, European Community Respiratory Health Survey (ECRHS) with the Nordic-Baltic Respiratory Health in Northern Europe (RHINE) and the FinEsS-studies in Finland, Estonia and Sweden. Bilateral international collaborative research also occurs. In Sweden, collaborative research primarily include the OLIN-studies and the Västra Götaland children study in addition to those projects that fully or partially funded by the KRC. Several researchers are involved and researchers responsible for different modules are listed in a supplement (Research teams within the framework of WSAS).
West Sweden Asthma Study has several purposes. The short-term aim is to investigate if asthma and respiratory symptoms and allergic rhinitis still are increasing in society. In the long-term perspective, the purpose is to find well-defined and clinically relevant main phenotypes, or subgroups, of asthma. Asthma is a heterogeneous disease, in reality a syndrome, consisting of several disease groups with different clinical picture, different prognosis, different risk factor patterns and different response to treatment. Knowledge of the main phenotypes is still extremely limited and fragmentary. It is important for patients with asthma to get a quick diagnosis and to benefit from a relevant and for each individual correct treatment. In order to implement the phenotyping of asthma both a large statistical power, so that findings are not to be explained by chance, and a good representation, i.e. that people with asthma in the study corresponds to asthma in the community, are required.
The initial phase was a large questionnaire study where the study sample consisted of 30 000 randomly selected people aged 16-75 years in Västra Götaland. Over 18 000 people responded to the comprehensive survey. A specific non-response study was conducted among a sample of those who did not respond. Two original articles are already published from the survey study and non-response study, and 3 more manuscripts are submitted to scientific journals for evaluation for publication.
The study's second phase consists of extensive clinical studies. Currently examinations of a random sample of 2 000 people who responded to the questionnaire and of all persons who indicated that they have asthma are taking place. In total around 3600 people will be invited to the clinical investigations. The study design and methods are described in more detail in a supplement. Several sub-projects are included and responsible researchers for these projects are listed in the supplement.
The third phase is planned and consists of sophisticated laboratory studies of inflammation in asthma and proteomics. These studies are based on results from the ongoing clinical phase. These studies are necessary, especially for a successful phenotyping of asthma. At a later stage genetic studies will also performed.


Patient - lungundersöks
Page Manager: Madeleine Ahrnens|Last update: 11/17/2009

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