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Patients with sensory hyperreactivity

Ewa Ternesten Hasséus, Allergy Unit , Sahlgrenska University Hospital, Göteborg, Sweden

Symptoms, health-related quality of life, coping and cough sensitivity to inhaled capsaicin in patients with sensory hyperreactivity.

Patients with airway symptoms induced by chemicals and scents are often misinterpreted as having asthma and/or allergy. The patients have been suggested to suffering from airway sensory hyperreactivity (SHR), since they have increase cough sensitivity to inhaled capsaicin, which is known to reflect the sensory nerve reactivity of the airways. A capsaicin inhalation test and a questionnaire has been developed for identify patients with SHR. A 5-year follow-up study, in patients with chemically induced airway symptoms have shown that the patients had persisting symptoms induced by chemicals and scents that cause a long-term reduction in health related quality of life (HRQL), and a persistent increase in capsaicin cough sensitivity. Almost all patients who participated in the study also suffered from more or less unexplained chronic idiopathic cough (CIC). Chemical sensitivity as an inducing factor to CIC is seldom or never discussed. The question has thus been raised of whether patients with CIC represent a discrete clinical entity with an as-yet unidentified underlying pathology. With a view to formulating comprehensive and effective public health and clinical approaches to patients with SHR, there is a need to sort out related nomenclature, gender differences, HRQL, coping strategies and environmental causation, Education of health-care professionals as well as patients is crucial and it seems to be increasing needs for supportive care and patient education programmes.

The overall aim of this program is to explore SHR from several points of view. In a longitudinal perspective we aim to follow a group of patients with SHR and to study different factors, concerning cough sensitivity to capsaicin, symptoms, trigger factors and HRQL. In another study we want to analyse if SHR can be one explanation for CIC. Patients will be answering questionnaires about symptoms, trigger factors and HRQL. They will also be asked to perform a capsaicin inhalation test. Furthermore we want to compare two different HRQL-questionnaires, regarding validity, responsiveness and suitability as outcome measures in patients with SHR. Coping strategies will also be studied using the Jalowiec coping scale (JCS-40) questionnaire.

Page Manager: Madeleine Ahrnens|Last update: 11/30/2009

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