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Proteomic identification of clinically relevant biomarkers in specific asthma phenotypes

Serena O'Neil and Linda Ekerljung
Krefting Research Centre, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

Background

Asthma has been increasing over the second half of the past century all over the world. Asthma has been regarded as a single disease, however today; asthma is recognised as a complex disease with many different presentations and responses to treatment. The clinical studies of the phenotypes have so far been poorly developed and the reports are based on highly selected patient populations.

Aim

The two main aims of the project are to:

  1. Identify main clinical phenotypes of asthma based on clinical patient characteristics
  2. Compare the proteomes of different phenotypes of asthma in order to identify specific biomarkers.

Method

The aims will be addressed using epidemiology and proteomic studies. The main phenotypes will be identified using patient data, including patient history, exposures, lung function variables, allergic sensitisation, exhaled NO and inflammatory cells, mainly eosinophils and neutrophils, from blood and nasal lavage.
The proteomic studies of main phenotypes will be performed using quantitative proteomics (iTRAQ®). Biomarker candidates will be selected from the expression levels and network analysis, followed by confirmation using another method.

Importance

Comparing asthma phenotypes using proteomics to identify unique biomarkers, will aid in the diagnosis and treatment of asthma.

LC MS/MS chromatogram

LC MS/MS chromatogram

Page Manager: Madeleine Ahrnens|Last update: 11/17/2009
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