Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Depletion of immune effector cells for treatment of
allergic diseases

Zou Xiang
Mucosal Immunobiology and Vaccine Research Center, Department of Microbiology and Immunology, Sahlgrenska Academy, University of Göteborg, Göteborg, Sweden

Allergic inflammation involves the participation of a wide variety of cell types including mast cells, basophils and eosinophils. All of these inflammatory effector cells express receptors for immunoglobulin molecules and signalling through these receptors mediates the allergic cellular events. My research interest focuses on an inhibitory Fc receptor, FcgammaRIIB, which binds IgG, especially in the form of antigen-IgG immune-complexes. Co-crosslinking of FcgammaRIIB with activatory receptors by immune-complexes dampens cellular activation. FcgammaRIIB-deficient mice produce higher levels of immunoglobulin than normal mice in response to immunization. These mice also exhibit more vascular and mucosal permeability, which probably reflects enhanced activation of FcgammaRIIB-deficient mast cells. Therefore FcgammaRIIB is critical for down-modulating immune responses, and provides a mechanism to limit the duration of immune responses that may otherwise lead to allergy. Our aim is to study the effects of the interaction between FcgammaRIIB and immune-complexes composed of allergen and IgG on the regulation of allergic inflammation. We will use both FcgammaRIIB-deficient and normal wildtype control mice to characterize the possible outcomes of this interaction in various types of allergic responses, especially with regard to the function of immune effector cells such as mast cells, basophils and eosinophils. This project intends to provide a better understanding of the mechanisms involved in allergy as well as its treatment, e.g. allergen immunotherapy.

Page Manager: Madeleine Ahrnens|Last update: 10/15/2014
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?