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Is allergic inflammation in the gastro-intestinal tract connected to aggravated asthma during the pollen season?

Georgios Rentzos, Senior consultant
Allergy unit, Sahlgrenska University Hospital, Gothenburg, Sweden

Many patients with pollen allergy also have food related gastrointestinal disorders particularly during the pollen season, and some of these patients also suffer from asthma. We have previously shown that birch pollen allergic patients display an aggravated allergic inflammation in the small intestinal mucosa related to birch pollen exposure. It is also known that pollen allergic patients get worse in their asthma during the pollen season. We will therefore investigate if patients with both asthma and rhinoconjunctivitis show an aggravated allergic inflammation in the gastrointestinal mucosa during the pollen season as compared with patients with only rhinoconjunctivitis. We will also investigate whether the symptoms are connected to intake of pollen related food constituents. We will collect allergy connected clinical and serological data from birch pollen allergic patients with or without asthma. The selected patient will be subjected to gastroscopy and biopsies will be taken from the
duodenal mucosa both during and outside the birch pollen season. The degree of allergic inflammation in the biopsies will be quantified by immunohistochemistry and serum IgE reactive patterns to birch related food components will be analysed by allergen micro-arrays. These data will be merged with patient derived subjective symptoms and any possible connection to food intake obtained in a questionnaire.

Page Manager: Madeleine Ahrnens|Last update: 11/18/2009
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