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Three new articles about exosomes

News: Aug 29, 2016

The article ”Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation” was published in the Journal of Translational Medicine in June 2014.

Authors: Lässer C, O'Neil SE, Shelke GV, Sihlbom C, Hansson SF, Gho YS, Lundbäck B, Lötvall J.

This study is based on nasal lavage fluid samples from the West Sweden Asthma Study (WSAS) and shows that exosomes from the upper respiratory tract contains proteins that are associated with immune functions. Furthermore, the study shows that exosomes can stimulate immune cells to migrate, which could play a role when white blood cells move into inflammatory areas. We also saw differences in the expression of several proteins in the exosomes isolated from nasal lavage fluid from subjects with respiratory diseases such as asthma and chronic rhinosinusitis compared with exosomes from healthy subjects. This indicates that the signals sent between airway cells via exosomes in chronic inflammation is different from that which is sent from a healthy epithelium, which could have important clinical implications in disease progression.

http://www.translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0927-4


The article ”RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in cancer” was published in Biomaterials in June 2016.

Authors: Lunavat TR, Jang SC, Nilsson L, Park HT, Repiska G, Lässer C, Nilsson JA, Gho YS, Lötvall J.

To develop RNA-based therapeutics, it is important to have vectors which transport and deliver the RNA molecule into the recipient cell. Exosomes have the potential to act as such a vector, but their yield is relatively low in a cell culture system. This study, which is a collaboration between Krefting Research Centre, Sahlgrenska Cancer Centre and the Pohang University of Science and Technology in South Korea, shows that artificial exosome-like nanovesicles (created by sequentially force cells through a filter) can be used to deliver RNA to recipient cells. The study shows that these nanovesicles can be both exogenous and endogenous loaded with siRNAs (a type of RNA molecule that can suppress the expression of genes) and that the RNA molecule is functional in the recipient cell by reducing the expression of the target gene.

http://www.sciencedirect.com/science/article/pii/S0142961216302782


The article “Methods for the physical characterization and quantification of extracellular vesicles in biological samples” was published in Biochimica et Biophysica Acta (BBA) - General Subjects in August 2016.

Authors: Rupert DLM, Claudio V, Lässer C, Bally M.

This article is a review article published in collaboration between Krefting Research Centre and the Department of Physics at Chalmers. The article presents the different techniques that can be used to quantify and characterize the physical properties of extracellular vesicles, such as structure, size, buoyant density, optical properties and zeta potential. The article summarizes how these techniques work and how they are implemented within the field of extracellular vesicles. Furthermore, it discusses advantages and limitations of these techniques.

http://www.sciencedirect.com/science/article/pii/S0304416516302756

 

BY: Cecilia Lässer

Page Manager: Eva-Marie Romell|Last update: 11/17/2009
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Utskriftsdatum: 2017-11-20